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hybridization$36360$ - translation to german
![mix]] and [[Great Dane]] shows the wide range of dog breed sizes created using selective breeding.](https://commons.wikimedia.org/wiki/Special:FilePath/Big and little dog 1.jpg?width=200 "mix]] and [[Great Dane]] shows the wide range of dog breed sizes created using selective breeding.")
![Researchers at the [[USDA]] have selectively bred carrots with a variety of colors.](https://commons.wikimedia.org/wiki/Special:FilePath/Carrots of many colors.jpg?width=200 "Researchers at the [[USDA]] have selectively bred carrots with a variety of colors.")
![Selective breeding transformed [[teosinte]]'s few fruitcases (left) into modern [[maize]]'s rows of exposed kernels (right).](https://commons.wikimedia.org/wiki/Special:FilePath/Cornselection.jpg?width=200 "Selective breeding transformed [[teosinte]]'s few fruitcases (left) into modern [[maize]]'s rows of exposed kernels (right).")
![A [[Belgian Blue]] cow. The defect in the breed's [[myostatin]] [[gene]] is maintained through linebreeding and is responsible for its accelerated lean muscle growth.](https://commons.wikimedia.org/wiki/Special:FilePath/Sectio caesarea.jpg?width=200 "A [[Belgian Blue]] cow. The defect in the breed's [[myostatin]] [[gene]] is maintained through linebreeding and is responsible for its accelerated lean muscle growth.")
Definition
Uh-oh, here's a new off-the-wall comedy. Time to apply the fish test.
Wikipedia
Sequencing by hybridization is a class of methods for determining the order in which nucleotides occur on a strand of DNA. Typically used for looking for small changes relative to a known DNA sequence. The binding of one strand of DNA to its complementary strand in the DNA double-helix (known as hybridization) is sensitive to even single-base mismatches when the hybrid region is short or if specialized mismatch detection proteins are present. This is exploited in a variety of ways, most notably via DNA chips or microarrays with thousands to billions of synthetic oligonucleotides found in a genome of interest plus many known variations or even all possible single-base variations.
The type of sequencing by hybridization described above has largely been displaced by other methods, including sequencing by synthesis, and sequencing by ligation (as well as pore-based methods). However hybridization of oligonucleotides is still used in some sequencing schemes, including hybridization-assisted pore-based sequencing, and reversible hybridization.
